A section of the A16 at Algarkirk is expected to be closed into the early hours of Monday morning following a crash.
The collision involved a lorry and a car at around 12.20pm on Sunday, November 11.
One person was seriously injured.
A Lincolnshire Police spokesperson said in a statement: “There is no more information at this time. We will update as soon as we have more.
“Please avoid the area if possible as there is likely to be disruption for some time.
“Diversions are in place.”