Potholes on the A1084 near Bigby will be patched next week before the road is surface dressed at a later date.
Work will be taking place for two days from Thursday, January 11 between the junction with the B1434 and the junction with Kettleby Lane.
Traffic will be diverted along the A1084, A18, A1173 and A1084 and vice versa.
Access for businesses will be maintained from the westbound end of the closure.
Mark Heaton, programme leader – surfacing and patching at Lincolnshire County Council, said: “We’re planning to surface dress this road in future, which will greatly extend its life.
“However, before we do that, we need to repair failing sections of the carriageway.
“We apologise for any inconvenience caused, and would encourage motorists to allow additional time for their journeys or find an alternative route.”