The A607 at Barkston will be closed overnight for two nights later this month for resurfacing.
Failing sections of the carriageway will be replaced on the evenings of Monday, January 29 and Tuesday, January 30.
The road will be closed to all traffic from 7.30pm each night, reopening by 6am each morning.
A signed diversion will be in place during that time, directing traffic via the A607, B1174, A52, B6403, and A153.
Mark Heaton, programme leader for surfacing and patching at Lincolnshire County Council, said: “It’s important we get these worn out sections of road replaced.
“However, to minimise the impact on motorists we’ll be doing the work overnight, with the road open as usual during the daytime.
“We apologise for any inconvenience caused.”