A section of the B1225 will close to allow for resurfacing works.
The road will be closed between Main Road and the Market Stainton junction throughout the project, which is set to begin on Thursday, June 22.
A signed diversion will be in place, with traffic directed via the B1225, A158, A157, B1225 and vice versa.
The project is expected to be completed by Sunday, July 9.
Local access will be maintained for residents and businesses, although there will be a site speed limit of 10mph.
Steve Brooks, senior project leader, said: “This section of road has reached the end of its serviceable life. Resurfacing it will ensure it remains fit for purpose for many years.
“We’ll be on site from 8am to 7pm Monday to Sunday, but the road will need to remain closed around the clock because of the type of material we have to use.
“We would advise drivers to allow more time for their journeys, and apologise for any inconvenience that may be caused.”