The M180 close to junction 3 has been closed after a crash between two lorries.
The crash on the eastbound carriageway happened shortly after 8.10am on Thursday, January 5.
One of the drivers is believed to have sustained serious but not life-threatening injuries.
The motorway has been closed in both directions to allow the air ambulance to land and take the injured driver to hospital.
A spokesperson for Humberside Police said: “Please be patient and allow the emergency services carry out their duties – we hope to have everyone on their way at the earliest opportunity.”