A woman has died and two other people have been taken to hospital with serious injuries after a crash on the A52 at Newton at around 4pm this afternoon.
Two vehicles were involved in the collision: a heavy goods vehicle and a blue Suzuki car.
The road remains closed to allow police to investigate and recover the vehicles.
Police estimate the road will reopen at around 10pm this evening.
Officers are appealing for anyone who was travelling along the A52 near Osbournby and Newton just before 4pm and who may have seen either vehicle travelling on the A52, or who witnessed the collision itself.
They can contact the Serious Collision Investigation Team by calling 101 quoting incident 314 of 27/7.